SPECIAL FEATURE:

Lorenz C. Hofbauer and Martina Rauner

Minireview: Live and Let Die: Molecular Effects of Glucocorticoids on Bone Cells
Mol Endocrinol 2009 23: 1525-1531, doi:10.1210/me.2009-0069 [Abstract] [Full Text] [PDF]  
While traditional glucocorticoids have the drawback of impairing bone cell function through several distinct molecular mechanisms, newer selective receptor agonists may have bone-sparing effects.

ORIGINAL RESEARCH:

Woo-Kyun Kim, Vicente Meliton, Kye Won Park, Cynthia Hong, Peter Tontonoz, Pawel Niewiadomski, James A. Waschek, Sotirios Tetradis, and Farhad Parhami

Negative Regulation of Hedgehog Signaling by Liver X Receptors
Mol Endocrinol 2009 23: 1532-1543, doi:10.1210/me.2008-0453 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Liver X Receptor activation by pharmacological ligands inhibits hedgehog signaling in vitro and in vivo, suggesting a novel strategy for hedgehog pathway modulation.

Dörthe L. Ahlbory-Dieker, Brenda D. Stride, Gabriele Leder, Jenny Schkoldow, Susanne Trölenberg, Henrik Seidel, Christiane Otto, Anette Sommer, Malcolm G. Parker, Günther Schütz, and Tim M. Wintermantel

DNA Binding by Estrogen Receptor- Is Essential for the Transcriptional Response to Estrogen in the Liver and the Uterus
Mol Endocrinol 2009 23: 1544-1555, doi:10.1210/me.2009-0045 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Gene expression analysis in a mutant ER knock-in mouse model shows that estrogen response requires a functional DNA binding domain.

Dae-Hwan Kim, Jeongkyung Lee, Bora Lee, and Jae W. Lee

ASCOM Controls Farnesoid X Receptor Transactivation through Its Associated Histone H3 Lysine 4 Methyltransferase Activity
Mol Endocrinol 2009 23: 1556-1562, doi:10.1210/me.2009-0099 [Abstract] [Full Text] [PDF]  
Histone H3-lysine-4-methyltransferases MLL3 and MLL4, mediate transactivation by metabolic nuclear receptors, including FXR.

Paul W. Howard, Shall F. Jue, and Richard A. Maurer

Expression of the Synaptotagmin I Gene Is Enhanced by Binding of the Pituitary-Specific Transcription Factor, POU1F1
Mol Endocrinol 2009 23: 1563-1571, doi:10.1210/me.2009-0111 [Abstract] [Full Text] [PDF]  
POU1F1 binds to the synaptotagmin I gene and is sufficient and necessary for full activation of the synaptotagmin I promoter in GH3 cells.

Jannick Pétremand, Natasa Bulat, Anne-Christine Butty, Carine Poussin, Sabine Rütti, Karin Au, Sujoy Ghosh, Vincent Mooser, Bernard Thorens, Jiang-Yan Yang, Christian Widmann, and Gérard Waeber

Involvement of 4E-BP1 in the Protection Induced by HDLs on Pancreatic β-Cells
Mol Endocrinol 2009 23: 1572-1586, doi:10.1210/me.2008-0448 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Inhibition of 4E-BP1 up-regulation is a stimulus-specific mechanism by which HDLs protect beta cells from apoptosis.

Ushma R. Jag, Jiri Zavadil, and Frederick M. Stanley

Insulin Acts through FOXO3a to Activate Transcription of Plasminogen Activator Inhibitor Type 1
Mol Endocrinol 2009 23: 1587-1602, doi:10.1210/me.2008-0421 [Abstract] [Full Text] [PDF]  
Insulin increased-PAI-1 transcription in multiple cell types is mediated by FoxO3a and is independent of Akt-phosphorylation that increases FoxO3a phosphorylation in nuclear and cytoplasmic compartments.

Qiang Wang, Ann M. Ratchford, Maggie M.-Y. Chi, Erica Schoeller, Antonina Frolova, Tim Schedl, and Kelle H. Moley

Maternal Diabetes Causes Mitochondrial Dysfunction and Meiotic Defects in Murine Oocytes
Mol Endocrinol 2009 23: 1603-1612, doi:10.1210/me.2009-0033 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Maternal diabetes results in structural and spatial dysfunction of murine oocyte mitochondria and induces spindle defects and chromosome misalignment in oocytes.

Hong Wang, Aileen X. Wang, Zhenqi Liu, Weidong Chai, and Eugene J. Barrett

The Trafficking/Interaction of eNOS and Caveolin-1 Induced by Insulin Modulates Endothelial Nitric Oxide Production
Mol Endocrinol 2009 23: 1613-1623, doi:10.1210/me.2009-0115 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Insulin induces PI3K activity/palmitoylation-sensitive translocation and association of eNOS and caveolin-1 to the plasma membrane of vascular endothelial cells leading to regulation of nitric oxide production.

Laura J. Cobb, Hemal Mehta, and Pinchas Cohen

Enhancing the Apoptotic Potential of Insulin-Like Growth Factor-Binding Protein-3 in Prostate Cancer by Modulation of CK2 Phosphorylation
Mol Endocrinol 2009 23: 1624-1633, doi:10.1210/me.2008-0365 [Abstract] [Full Text] [PDF]  
Phosphorylation of IGFBP-3 by the oncogenic kinase CK2 inhibits its nuclear localization and ability to induce apoptosis in prostate cancer.

Stefania Catalano, Ines Barone, Cinzia Giordano, Pietro Rizza, Hongyan Qi, Guowei Gu, Rocco Malivindi, Daniela Bonofiglio, and Sebastiano Andò

Rapid Estradiol/ER Signaling Enhances Aromatase Enzymatic Activity in Breast Cancer Cells
Mol Endocrinol 2009 23: 1634-1645, doi:10.1210/me.2009-0039 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Estradiol induces rapid up-regulatory effects on aromatase activity in MCF-7 breast cancer cells through an enhanced tyrosine phosphorylation of the enzyme mediated by c-Src kinase.

Song Ling Poon, Gareth T. Hammond, and Peter C. K. Leung

Epidermal Growth Factor-Induced GnRH-II Synthesis Contributes to Ovarian Cancer Cell Invasion
Mol Endocrinol 2009 23: 1646-1656, doi:10.1210/me.2009-0147 [Abstract] [Full Text] [PDF]  
GnRH-II induced by EGF via ERK1/2 and pCREB/C/EBPb signaling acts in an autocrine/paracrine manner to enhance ovarian cancer cell invasion.

Mohamad Zubair, Sanae Oka, Keith L. Parker, and Ken-ichirou Morohashi

Transgenic Expression of Ad4BP/SF-1 in Fetal Adrenal Progenitor Cells Leads to Ectopic Adrenal Formation
Mol Endocrinol 2009 23: 1657-1667, doi:10.1210/me.2009-0055 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Overexpression of Ad4BP/SF-1 induces ectopic adrenal formation. This increased tissue size doesn’t result from cell proliferation, but rather increased commitment to the steroidogenic cell lineage.

Estelle Chamoux, Julie Couture, Martine Bisson, Jean Morissette, Jacques P. Brown, and Sophie Roux

The p62 P392L Mutation Linked to Paget’s Disease Induces Activation of Human Osteoclasts
Mol Endocrinol 2009 23: 1668-1680, doi:10.1210/me.2009-0066 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Over-expression of p62 and a p62 P392L mutation induce important shifts in the pathways activated by RANKL and up-regulate osteoclast functions in Paget’s disease of bone.

Gyun Jee Song, Nathalie Fiaschi-Taesch, and Alessandro Bisello

Endogenous Parathyroid Hormone-Related Protein Regulates the Expression of PTH Type 1 Receptor and Proliferation of Vascular Smooth Muscle Cells
Mol Endocrinol 2009 23: 1681-1690, doi:10.1210/me.2009-0098 [Abstract] [Full Text] [PDF]  
Endogenously secreted N-terminal fragments of parathyroid hormone-related protein regulate PTH1R levels and proliferation of vascular smooth muscle cells in an auto/paracrine fashion.

Matthew J. Mahon

The Parathyroid Hormone 1 Receptor Directly Binds to the FERM Domain of Ezrin, an Interaction that Supports Apical Receptor Localization and Signaling in LLC-PK1 Cells
Mol Endocrinol 2009 23: 1691-1701, doi:10.1210/me.2009-0164 [Abstract] [Full Text] [PDF]  
Direct interactions with the FERM domain of activated ezrin mediate apical localization of the PTH 1 receptor in LLC-PK1 cells, a proximal tubule cell model.

RESEARCH RESOURCE:

Sebastian Rieck, Peter White, Jonathan Schug, Alan J. Fox, Olga Smirnova, Nan Gao, Rana K. Gupta, Zhao V. Wang, Philipp E. Scherer, Mark P. Keller, Alan D. Attie, and Klaus H. Kaestner

The Transcriptional Response of the Islet to Pregnancy in Mice
Mol Endocrinol 2009 23: 1702-1712, doi:10.1210/me.2009-0144 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Gene expression analysis in islets during pregnancy highlights potential novel factors associated with both proliferative and survival signals required for islet expansion.

TRANSLATIONAL HIGHLIGHTS FROM JCEM:

Dual Inhibition of Mitogen-Activated Protein Kinase and Mammalian Target of Rapamycin in Differentiated and Anaplastic Thyroid Cancer
Mol Endocrinol 2009 23: 1713-1714 [Full Text] [PDF]  

Audrey Robinson-White, Ioannis Bossis, Hui-Pin Hsiao, Maria Nesterova, Wolfgang W. Leitner, and Constantine A. Stratakis

8-Cl-Adenosine Inhibits Proliferation and Causes Apoptosis in B-Lymphocytes via Protein Kinase A-Dependent and Independent Effects: Implications for Treatment of Carney Complex-Associated Tumors
Mol Endocrinol 2009 23: 1713 [Full Text] [PDF]  

Anat Ben-Shlomo, Herbert Schmid, Kolja Wawrowsky, Oxana Pichurin, Erika Hubina, Vera Chesnokova, Ning-Ai Liu, Michael Culler, and Shlomo Melmed

Differential Ligand-Mediated Pituitary Somatostatin Receptor Subtype Signaling: Implications for Corticotroph Tumor Therapy
Mol Endocrinol 2009 23: 1714-1715 [Full Text] [PDF]  

Lyndal J. Tacon, Patsy S. Soon, Anthony J. Gill, Angela S. Chou, Adele Clarkson, Johan Botling, Peter L. H. Stalberg, Britt M. Skogseid, Bruce G. Robinson, Stanley B. Sidhu, and Roderick J. Clifton-Bligh

The Glucocorticoid Receptor Is Overexpressed in Malignant Adrenocortical Tumors
Mol Endocrinol 2009 23: 1714 [Full Text] [PDF]  

Pei-an Betty Shih, Lei Wang, Stephane Chiron, Gen Wen, Caroline Nievergelt, Manjula Mahata, Srikrishna Khandrika, Fangwen Rao, Maple M. Fung, Sushil K. Mahata, Bruce A. Hamilton, and Daniel T. O'Connor

Peptide YY (PYY) Gene Polymorphisms in the 3'-Untranslated Region and Proximal Promoter Regions Regulate Cellular Gene Expression and PYY Secretion and Metabolic Syndrome Traits in Vivo
Mol Endocrinol 2009 23: 1715 [Full Text] [PDF]  

Marco Volante, Ida Rapa, Manoj Gandhi, Gianni Bussolati, Daniela Giachino, Mauro Papotti, and Yuri E. Nikiforov

RAS Mutations Are the Predominant Molecular Alteration in Poorly Differentiated Thyroid Carcinomas and Bear Prognostic Impact
Mol Endocrinol 2009 23: 1715 [Full Text] [PDF]  

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