| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on March 20, 2002
Accepted on October 10, 2002
1 Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institutet, S-171 77 Stockholm, Sweden. MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, University College London, London WC1E 6BT, UK Molecular Endocrinology 2002 In press
* To whom correspondence should be addressed. E-mail: maria.bondesson{at}cmb.ki.se.
Thyroid hormone induces differentiation of many different tissues in mammals, birds and amphibians. The different tissues all differentiate from proliferating precursor cells, and the normal cell cycle is suspended while cells undergo differentiation. We have investigated how thyroid hormone affects the expression of the E2F-1 protein, a key transcription factor that controls G1 to S-phase transition. We show that during thyroid hormone-induced differentiation of embryonic carcinoma cells and of oligodendrocyte precursor cells, the levels of E2F-1 mRNA and E2F-1 protein decrease. This is caused by the thyroid hormone receptor regulating the transcription of the E2F-1 gene. The thyroid hormone receptor binds directly to a negative thyroid hormone response element called the Z-element, in the E2F-1 promoter. When bound, the thyroid hormone receptor activates transcription in the absence of ligand, but represses transcription in the presence of ligand. In addition, liganded thyroid hormone receptor represses transcription of the S-phase-specific DNA polymerase 
, thymidine kinase and dihydropholate reductase genes. These results suggest that thyroid hormone-induced withdrawal from the cell cycle takes place through the repression of S-phase genes. We suggest that this is an initial and crucial step in thyroid hormone-induced differentiation of precursor cells.
NURSA Molecule Pages Link:
This article has been cited by other articles:
 |
|
 |
|
  L. Quignodon, C. Grijota-Martinez, E. Compe, R. Guyot, N. Allioli, D. Laperriere, R. Walker, P. Meltzer, S. Mader, J. Samarut, et al. A combined approach identifies a limited number of new thyroid hormone target genes in post-natal mouse cerebellum J. Mol. Endocrinol., July 1, 2007; 39(1): 17 - 28. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Michienzi, B. Bucci, C. Verga Falzacappa, V. Patriarca, A. Stigliano, L. Panacchia, E. Brunetti, V. Toscano, and S. Misiti 3,3',5-Triiodo-L-thyronine inhibits ductal pancreatic adenocarcinoma proliferation improving the cytotoxic effect of chemotherapy J. Endocrinol., May 1, 2007; 193(2): 209 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Flamant, K. Gauthier, and J. Samarut Thyroid Hormones Signaling Is Getting More Complex: STORMs Are Coming Mol. Endocrinol., February 1, 2007; 21(2): 321 - 333. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Hashimoto, M. Yamada, S. Matsumoto, T. Monden, T. Satoh, and M. Mori Mouse Sterol Response Element Binding Protein-1c Gene Expression Is Negatively Regulated by Thyroid Hormone Endocrinology, September 1, 2006; 147(9): 4292 - 4302. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nygard, N. Becker, B. Demeneix, K. Pettersson, and M. Bondesson Thyroid hormone-mediated negative transcriptional regulation of Necdin expression. J. Mol. Endocrinol., June 1, 2006; 36(3): 517 - 530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Schoonover, M. M. Seibel, D. M. Jolson, M. J. Stack, R. J. Rahman, S. A. Jones, C. N. Mariash, and G. W. Anderson Thyroid Hormone Regulates Oligodendrocyte Accumulation in Developing Rat Brain White Matter Tracts Endocrinology, November 1, 2004; 145(11): 5013 - 5020. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Billon, A. Terrinoni, C. Jolicoeur, A. McCarthy, W. D. Richardson, G. Melino, and M. Raff Roles for p53 and p73 during oligodendrocyte development Development, March 15, 2004; 131(6): 1211 - 1220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Holsberger, S. Jirawatnotai, H. Kiyokawa, and P. S. Cooke Thyroid Hormone Regulates the Cell Cycle Inhibitor p27Kip1 in Postnatal Murine Sertoli Cells Endocrinology, September 1, 2003; 144(9): 3732 - 3738. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
