help button home button Endocrine Society Molecular Endocrinology ENDO 08 Sessions Library
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
This version published online on August 22, 2002
Molecular Endocrinology, doi:10.1210/me.2002-0094
Molecular Endocrinology Vol. 0, No. 2002 200200941-
doi:10.1210/me.2002-0094
Copyright © 2002 by the Endocrine Society.
This Article
Right arrow Author Manuscript (PDF)
Right arrow All Versions of this Article:
16/11/2645    most recent
Author Manuscript (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by U, S. H.
Right arrow Articles by Saljooque, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by U, S. H.
Right arrow Articles by Saljooque, F.
Right arrowPubmed/NCBI databases
Medline Plus Health Information
*Stem Cells

Submitted on March 7, 2002
Accepted on July 26, 2002

Fetal Brain Progenitor Cells are instructed to transdifferentiate to Fates outside the Nervous System

Sang Hoi U1*, Warren Alilain1, and Farid Saljooque1

1 Division of Neurological Surgery, Veterans Administration San Diego Health Care System And The University of California {ndash}San Diego, San Diego, California

* To whom correspondence should be addressed. E-mail: hoisang{at}ucsd.edu.

Central nervous system (CNS) stem cells give rise to neurons and glia when exposed to specific trophic factors. In our studies with rat fetal brain derived stem cells (RSCs), we showed that they could be induced to express the developmentally regulated transcription factors and cell markers characteristic of cells derived from another germ layer, e.g., pituitary cells. Therefore, RSCs do not seem to be restricted to a defined developmental fate. They may retain pluripotentiality and can be redirected to develop into other cell types not found in the brain provided the correct set of stimuli is present. This multipotent developmental behavior also suggests that instructive signals are operative.
Key words: Brain stem cells • differentiation • pituitary cells • conditioned media • co-culture • transcription factors




This article has been cited by other articles:


Home page
 EndocrinologyHome page
O. Krylyshkina, J. Chen, L. Mebis, C. Denef, and H. Vankelecom
Nestin-Immunoreactive Cells in Rat Pituitary Are neither Hormonal nor Typical Folliculo-Stellate Cells
Endocrinology, May 1, 2005; 146(5): 2376 - 2387.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
C. J Burns, S. J Persaud, and P. M Jones
Stem cell therapy for diabetes: do we need to make beta cells?
J. Endocrinol., December 1, 2004; 183(3): 437 - 443.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2002 by The Endocrine Society