| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, University of Utah, Salt Lake City, Utah 84112-5331
Address all correspondence and requests for reprints to: Carl S. Thummel, Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, 15 North 2030 E, Room 5100, University of Utah, Salt Lake City, Utah 84112-5331.
The recent completion of the Drosophila genome sequence revealed 21 members of the nuclear receptor superfamily. Many of these genes are transcriptionally regulated by the steroid hormone ecdysone and play a role during the onset of metamorphosis, including the EcR/USP ecdysone receptor heterodimer. As a first step toward a genomic analysis of this gene family, we have characterized the temporal patterns of expression for all detectable nuclear receptor transcripts throughout major ecdysone-regulated developmental transitions in the life cycle: embryogenesis, a larval molt, puparium formation, and the prepupal-pupal transition. We find an unexpected close temporal relationship between DHR3, E75B, and ßFTZ-F1 expression after each major ecdysone pulse examined, reflecting the known cross-regulatory interactions of these genes in prepupae and suggesting that they act together at other stages in the life cycle. In addition, E75A, E78B, and DHR4 are expressed in a reproducible manner with DHR3, E75B, and ßFTZ-F1, suggesting that they intersect with this regulatory cascade. Finally, we find that known ecdysone-inducible primary-response transcripts are coordinately induced at times when the ecdysteroid titer is low, implying the existence of novel, as yet uncharacterized, temporal signals in Drosophila.
NURSA Molecule Pages Link:
This article has been cited by other articles:
 |
|
 |
|
  Y. Agawa, M. Sarhan, Y. Kageyama, K. Akagi, M. Takai, K. Hashiyama, T. Wada, H. Handa, A. Iwamatsu, S. Hirose, et al. Drosophila Blimp-1 Is a Transient Transcriptional Repressor That Controls Timing of the Ecdysone-Induced Developmental Pathway Mol. Cell. Biol., December 15, 2007; 27(24): 8739 - 8747. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Takemoto, E. Kuranaga, A. Tonoki, T. Nagai, A. Miyawaki, and M. Miura Local initiation of caspase activation in Drosophila salivary gland programmed cell death in vivo PNAS, August 14, 2007; 104(33): 13367 - 13372. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. D. Baker, R. B. Beckstead, D. J. Mangelsdorf, and C. S. Thummel Functional interactions between the Moses corepressor and DHR78 nuclear receptor regulate growth in Drosophila Genes & Dev., February 15, 2007; 21(4): 450 - 464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Palanker, A. S. Necakov, H. M. Sampson, R. Ni, C. Hu, C. S. Thummel, and H. M. Krause Dynamic regulation of Drosophila nuclear receptor activity in vivo Development, September 15, 2006; 133(18): 3549 - 3562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yoshiyama, T. Namiki, K. Mita, H. Kataoka, and R. Niwa Neverland is an evolutionally conserved Rieske-domain protein that is essential for ecdysone synthesis and insect growth Development, July 1, 2006; 133(13): 2565 - 2574. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Sun, Y. Wang, H. Qing, M. A. Christensen, Y. Liu, W. Zhou, Y. Tong, C. Xiao, Y. Huang, S. Zhang, et al. Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes FASEB J, May 1, 2005; 19(7): 739 - 749. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Novillo, S.-J. Won, C. Li, and I. P. Callard Changes in Nuclear Receptor and Vitellogenin Gene Expression in Response to Steroids and Heavy Metal in Caenorhabditis elegans Integr. Comp. Biol., January 1, 2005; 45(1): 61 - 71. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Pardee, J. Reinking, and H. Krause Nuclear Hormone Receptors, Metabolism, and Aging: What Goes Around Comes Around Sci. Aging Knowl. Environ., November 24, 2004; 2004(47): re8 - re8. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Gates, G. Lam, J. A. Ortiz, R. Losson, and C. S. Thummel rigor mortis encodes a novel nuclear receptor interacting protein required for ecdysone signaling during Drosophila larval development Development, January 1, 2004; 131(1): 25 - 36. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
